Despite warnings from public health professionals and the Bipartisan Commission on Biodefense, the country was caught unprepared for the COVID-19 pandemic. A new analysis from the Commission finds that the United States remains at catastrophic biological risk. Called Biodefense in Crisis: Immediate Action Needed to Address National Vulnerabilities, the report closely examines the extent of progress that has been made since the Commission released its seminal National Blueprint for Biodefense in 2015. Biodefense in Crisis provides a fresh assessment of governmental efforts to implement the Commission’s recommendations to prevent, deter, prepare for, detect, respond to, attribute, recover from, and mitigate biological threats. It also includes eleven updated recommendations based in-part on real-time learning during the pandemic.