The international community faced two major categories of security challenges in 2015. The first stems from “natural disasters” (e.g. infectious disease epidemics) and the second consists of “man-made threats” (e.g. radicalization and violence). The purpose of ICTS’ 18th annual security event was to focus on past lessons of international cooperation in combating human calamities and extremist actors as well as to assess the prospects for regional and global multilateral policies and actions in 2016. Panel Co-Chairs Governor Tom Ridge and Senator Joe Lieberman discussed the Panel’s objectives and recommendations.