The Athena Agenda: Advancing The Apollo Program for Biodefense provides recommendations to implement the 15 technology priorities described by the Commission in its 2021 report, The Apollo Program for Biodefense, and also identifies the US government organizations responsible for leadership, accountability, and engagement in public-private partnerships necessary for success. Athena is the Greek goddess of wisdom, reason, and strategy. The Commission named this report after her to represent and symbolize the insight, strategy, and technological craft needed to achieve the Apollo Program for Biodefense.